About 4 results found for searched term "mTOR inhibitor-12" (0.167 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M43384 | mTOR inhibitor-12 | mTOR |
| mTOR inhibitor-12 is a selective brain penetrant mTOR inhibitor without genotoxicity risk. | ||
| M10471 | MTI-31 (LXI-15029) | mTOR |
| LXI-15029; MTI31 | ||
| MTI-31 (LXI-15029) is a novel low-toxicity mTORC1/mTORC2 inhibitor, demonstrated a potent mTOR binding affinity with >5000 fold selectivity over the related PI3K family isoforms. MTI-31 inhibited mTORC1- and mTORC2 function at ≤120 nM in cellular assays. | ||
| M21167 | RMC-5552 | mTOR |
| The selective mTORC1 complex inhibitor RMC-4529 is a bidentate inhibitor that has a rapamycin-derived, FKBP12-induced heterologous mTOR inhibitor covalently linked to an active-site (orthologous) inhibitor. | ||
| M28992 | RapaLink-1 | mTOR |
| RapaLink-1, the third-generation bivalent mTOR inhibitor, combines Rapamycin with MLN0128 by an inert chemical linker. RapaLink-1 shows better efficacy than Rapamycin or mTOR kinase inhibitors (TORKi), potently blocking cancer-derived, activating mutants of mTOR. RapaLink-1 can cross the blood-brain barrier. RapaLink-1 binding to FKBP12 results in targeted and durable inhibition of mTORC1. RapaLink-1 plays an antithrombotic role in antiphospholipid syndrome by improving autophagy. Anticancer activity. | ||
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